职称：副研究员

学历：博士

电话：0591-22866373

电子邮件： ypxie@fzu.edu.cn

研究方向：微藻生物技术、生物发酵与代谢调控、生物物质分离纯化

教育工作经历：

2019.09-至今：福州海洋研究院海洋生物制造技术研发中心，常务副主任

2017.12-至今：海洋生物高值高质化利用技术创新服务平台，常务副主任

2017.03-至今：福建省海产品废弃物综合利用工程技术研究中心，常务副主任

2015.08-至今：福州市海产品高值化利用行业技术创新中心，常务副主任

2014.08-至今：威尼斯欢乐娱人v3676，助理研究员、副研究员

2012.09-2013.02：台湾成功大学张嘉修（Jo-Shu Chang）教授实验室，访学

2004.09-2014.07：厦门大学，化学化工学院，工学学士、工学硕士、工学博士

教学简介：

主讲本科生课程《生物分离工程》，硕士研究生课程《绿色生物制造》、《生物资源开发利用》。指导研究生多次获得国家奖学金、福建省优秀学位论文、威尼斯优秀学位论文、威尼斯研究生高水平学术成果奖等。

科研简介：

主要从事微藻生物技术、生物发酵与代谢调控、生物物质分离纯化等领域的研究工作。已先后主持国家“十三五”海洋经济创新发展示范项目子课题、国家自然科学基金项目、福建省自然科学基金项目、福州市市校（院所）科技合作项目和福州海洋研究院科技项目等10余项，并作为技术负责人参与福建省海洋高新产业发展专项、福建省科技厅高校产学合作重大项目、福州市省级海洋经济发展补助资金项目等10余项。以第一作者/通讯作者身份在Bioresour. Technol., Chem. Eng. J., Biotechnol. Biof. Biop., Algal Res., Mar. Drugs, Biotechnol. J., Biochem. Eng. J.等期刊上发表学术论文30余篇（中科院JCR大类学科1区Top期刊11篇，2区期刊12篇），作为共同作者发表学术论文30余篇，论文总被引1300余次（WOS），H指数24（WOS）。申请发明专利22件，已授权发明专利10件。获福建省科学技术进步奖三等奖1项。2021年入选福建省级高层次人才C类。

社会兼职：

民盟福建省生态环境委员会委员；民盟威尼斯委员会组织委员；福建省科技特派员；福州市科技特派员；担任Bioresour. Technol., Chem. Eng. J., Env. Sci. Ecotechnol., J. Hazard. Mater., J. Clean. Prod., Biotechnol. Biofuels, Algal Res., J. Taiwan Inst. Chem. E., Front. Microbiol., Front. Bioeng. Biotech., Biochem. Eng. J., Process Biochem., Int. J. Hydrogen Energ.等多本SCI期刊审稿人。

主要科研项目：

（1）国家“十三五”海洋经济创新发展示范项目，海洋生物高值高质化利用技术创新服务平台，2016-2019，子平台负责人。

（2）国家“十三五”海洋经济创新发展示范项目，海洋微藻高值化产品开发及产业链建设，2017-2019，子课题负责人。

（3）国家“十三五”海洋经济创新发展示范项目，鱿鱼内脏高值化产品开发及年产350吨海洋农用制品生产线建设，2017-2019，子课题负责人。

（4）国家自然科学基金应急管理项目，海洋衣藻自养积累叶黄素的调控机制研究， 2017-2017，主持。

（5）福建省海洋高新产业发展专项项目，海洋微藻开发利用与水产养殖废水净化的耦合处理关键技术研发，2016-2018，技术负责人。

（6）2019年福州市省级海洋经济发展补助资金项目，低值海鱼综合利用关键技术研发及产业化，2019-2020，技术负责人。

（7）2022年度福州海洋研究院科技项目，海洋小球藻高密度异养联产蛋白质和叶黄素的关键技术开发及中试熟化，2022-2024，主持。

代表性论文：（*为通讯作者）

(1) Ruijuan Ma#, Zhen Zhang#, Hong Fang, Xinyu Liu, Shih-Hsin Ho, Youping Xie*, Jianfeng Chen*. Unveiling the underlying molecular mechanisms of high lutein production efficiency in Chlorella sorokiniana FZU60 under a mixotrophy/photoautotrophy two-stage strategy by transcriptomic, physiological, and biochemical analyses. Biotechnology for Biofuels and Bioproducts, 2023, 16: 47.

(2) Hong Fang, Junjie Liu, Ruijuan Ma*, Yiping Zou, Shih-Hsin Ho, Jianfeng Chen, Youping Xie*. Functional characterization of lycopene b- and e-cyclases from a lutein-enriched green microalga Chlorella sorokiniana FZU60. Marine Drugs, 2023, 21: 418.

(3) Ruijuan Ma#, Yuanwei You#, Xinyu Liu, Shih-Hsin Ho, Youping Xie*, Jianfeng Chen*. Highly efficient co-production of fucoxanthin and eicosapentaenoic acid by heterotrophic cultivation of a newly isolated microalga Nitzschia sp. FZU62. Algal Research, 2023, 71: 103046.

(4) Youping Xie^#, Zhen Zhang^#, Ruijuan Ma^#, Xinyu Liu, Miao Miao, Shih-Hsin Ho, Jianfeng Chen, Yoong Kit Leonge, Jo-Shu Chang*. High-cell-density heterotrophic cultivation of microalga Chlorella sorokiniana FZU60 for achieving ultra-high lutein production efficiency. Bioresource Technology, 2022, 365: 128130.

(5) Hongling Ke^#, Ruijuan Ma^#, Xinyu Liu, Youping Xie*, Jianfeng Chen*. Highly effective peptide-calcium chelate prepared from aquatic products processing wastes: stickwater and oyster shells. LWT-Food Science and Technology, 2022, 168: 113947.

(6) Youping Xie, Kuan Shiong Khoo, Kit Wayne Chew, Vishno Vardhan Devadas, Sue Jiun Phang, Hooi Ren Lim, Saravanan Rajendran, Pau Loke Show*. Advancement of renewable energy technologies via artificial and microalgae photosynthesis. Bioresource Technology, 2022, 363: 127830.

(7) Ruijuan Ma^#, Xinyi Tao^#, Elvis T. Chua^#, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Youping Xie*, Jianfeng Chen. Enhancing astaxanthin production in Haematococcus pluvialis QLD by a pH steady NaHCO₃-CO₂-C/NH₄Cl-N culture system. Algal Research, 2022, 64: 102697.

(8) Ruijuan Ma^#, Zhen Zhang^#, Zhuzhen Tang, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Youping Xie*, Jianfeng Chen. Enhancement of co-production of lutein and protein in Chlorella sorokiniana FZU60 using different bioprocess operation strategies. Bioresources and Bioprocessing, 2021, 8: 82.

(9) Ruijuan Ma, Zhen Zhang, Shih-Hsin Ho, Chengxu Ruan, Jun Li, Youping Xie*, Xinguo Shi, Lemian Liu, Jianfeng Chen*. Two-stage bioprocess for hyper-production of lutein from microalga Chlorella sorokiniana FZU60: Effects of temperature, light intensity, and operation strategies. Algal Research, 2020, 52: 102119.

(10) Ruijuan Ma^#, Baobei Wang^#, Elvis T. Chua^#, Xurui Zhao, Kongyong Lu, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Youping Xie*, Yinghua Lu, Jianfeng Chen*. Comprehensive utilization of marine microalgae for enhanced co-production of multiple compounds. Marine Drugs, 2020, 18: 467.

(11) Youping Xie, Jun Li, Shih-Hsin Ho, Ruijuan Ma*, Xinguo Shi, Lemian Liu, Jianfeng Chen. Pilot-scale cultivation of Chlorella sorokiniana FZU60 with a mixotrophy/photoautotrophy two-stage strategy for efficient lutein production. Bioresource Technology, 2020, 314: 123767.

(12) Ruijuan Ma, Xurui Zhao, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Youping Xie*, Jianfeng Chen*, Yinghua Lu. Co-production of lutein and fatty acid in microalga Chlamydomonas sp. JSC4 in response to different temperatures with gene expression profiles. Algal Research, 2020, 47: 101821.

(13) Youping Xie, Jun Li, Ruijuan Ma, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Jianfeng Chen*. Bioprocess operation strategies with mixotrophy/photoinduction to enhance lutein production of microalga Chlorella sorokiniana FZU60. Bioresource Technology, 2019, 290: 121798.

(14) Ruijuan Ma, Xurui Zhao, Youping Xie*, Shih-Hsin Ho, Jianfeng Chen*. Enhancing lutein productivity of Chlamydomonas sp. via high-intensity light exposure with corresponding carotenogenic genes expression profiles. Bioresource Technology, 2019, 275: 416-420.

(15) Kongyong Lu^#, Xurui Zhao^#, Shih-Hsin Ho, Ruijuan Ma*, Youping Xie*, Jianfeng Chen. Biorefining and the functional properties of proteins from lipid and pigment extract residue of Chlorella pyrenoidosa. Marine Drugs, 2019, 17(8): 454.

(16) Youping Xie, Kongyong Lu, Xurui Zhao, Ruijuan Ma, Jianfeng Chen*, Shih-Hsin Ho*. Manipulating nutritional conditions and salinity-gradient stress for enhanced lutein production in marine microalga Chlamydomonas sp. Biotechnology Journal, 2019, 14: 1800380.

(17) Xurui Zhao, Ruijuan Ma, Xiaoting Liu, Shih-Hsin Ho, Youping Xie*, Jianfeng Chen*. Strategies related to light quality and temperature to improve lutein production of marine microalga Chlamydomonas sp. Bioprocess and Biosystems Engineering, 2019, 42: 435-443.

(18) Ying Shen, Sha Wang, Shih-Hsin Ho, Youping Xie*, Jianfeng Chen*. Enhancing lipid production in attached culture of a thermotolerant microalga Desmodesmus sp. F51 using light-related strategies. Biochemical Engineering Journal, 2018, 129: 119-128.

(19) Ying Shen, Huan Li, Wenzhe Zhu, Shih-Hsin Ho, Wenqiao Yuan, Jianfeng Chen, Youping Xie*. Microalgal-biochar immobilized complex: A novel efficient biosorbent for cadmium removal from aqueous solution. Bioresource Technology, 2017, 244: 1031-1038.

(20) Youping Xie, Xurui Zhao, Jianfeng Chen, Xuqiu Yang, Shih-Hsin Ho, Baobei Wang, Jo-Shu Chang, Ying Shen*. Enhancing cell growth and lutein productivity of Desmodesmus sp. F51 by optimal utilization of inorganic carbon sources and ammonium salt. Bioresource Technology, 2017, 244: 664-671.

(21) Youping Xie, Shih-Hsin Ho, Ching-Nen Nathan Chen, Chun-Yen Chen, Keju Jing, I-Son Ng, Jianfeng Chen, Jo-Shu Chang*, Yinghua Lu*. Disruption of thermo-tolerant Desmodesmus sp. F51 in high pressure homogenization as a prelude to carotenoids extraction. Biochemical Engineering Journal, 2016, 109: 243-251.

(22) Youping Xie, Yiwen Jin, Xianhai Zeng, Jianfeng Chen, Yinghua Lu, Keju Jing*. Fed-batch strategy for enhancing cell growth and C-phycocyanin production of Arthrospira (Spirulina) platensis under phototrophic cultivation. Bioresource Technology, 2015, 180: 281-287.

获奖情况：

2022年，威尼斯优秀硕士学位论文指导教师

2021年，福建省级高层次人才C类

2020年，福建省优秀硕士学位论文指导教师

2020年，威尼斯优秀硕士学位论文指导教师

2019年，福建省优秀硕士学位论文指导教师

2019年，威尼斯优秀硕士学位论文指导教师

2018年，2017年度福建省科技进步奖三等奖，福建省人民政府

2017年，Bioresource Technology期刊杰出审稿人，Elsevier

2017年，Algal Research期刊杰出审稿人，Elsevier

2016年，Biochemical Engineering Journal期刊杰出审稿人，Elsevier

个人网页：https://www.researchgate.net/profile/Youping_Xie

https://webofscience.clarivate.cn/wos/author/record/AAD-3105-2020